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Life-changing science

What’s the potential of Aruna Bio’s research?

What’s the potential of Aruna Bio’s research?

Quite simply, our unique and proprietary neural-derived exosomes will present those treating neurodegenerative diseases with a transformational platform – either as a stand-alone therapeutic or as a carrier for other molecules. Until now, the potential of exosomes in neurological science has not been fully explored. However, the research and development at Aruna Bio has the ability to revolutionize how a range of presently untreatable diseases could be managed.

Generic exosome

What are exosomes?

Exosomes are incredibly small “parcels” that are released by virtually every cell in the body. They are used by cells to deliver proteins and RNA (ribonucleic acid - a molecule essential in various biological roles in coding, decoding, regulation and expression of genes) throughout the body.

What do they do?

Cells use exosomes to regulate or communicate with either neighboring cells or those in other organs. Once the exosome arrives at the right destination, it is permitted through the target cell wall and the contents of the exosome are “unpacked”, delivering the proteins or RNA into the cell.
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Introducing AB126

Commercially available exosomes are often derived from tissue such as blood, which means they lack innate CNS specificity. However, AB126 are allogenic neural exosomes derived from neural stem cells. This means they possess many of the same proteins as the ‘parent’ cell and are coded for use in CNS applications. Select surface proteins are the key to the blood/brain barrier lock, so they are granted access to where other therapeutics cannot.
Generic Exosome icon

Generic exosome

Does not have inherent CNS specificity
Generic exosome illustration
AB126 exosome icon

AB126 (Neural exosome)

Derived from proprietary non-transformed neural stem cells
AB126 neural exosome

As a neural-derived exosome,
AB126 has two important innate abilities:

AB126 exosome

Proposed Mechanism
of Action

Innate therapeutic properties:

Reduces neuroinflammation
- a key feature of many neurodegenerative diseases
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Promotes neuroprotection
- by reducing cell death
‍
Stimulates neuroregeneration
- in areas of disease damage

Innate functional properties:

AB126 is highly effective at crossing the blood/brain barrier – so it can carry other molecules across
‍
AB126 is coded to target neural cells -
so the therapy arrives at the right place
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How does AB126 overcome the challenge of crossing the blood/brain barrier?

Crossing the blood/brain barrier has been a major obstacle to the delivery of CNS treatments into the brain at a clinically significant therapeutic dose. However, because neural exosomes have CNS specificity, their outer surface is equipped with receptors and surface proteins that the brain recognizes, and so neural exosomes are permitted to cross the barrier.
Crossing the Blood Brain Barrier illustration
We have also demonstrated the high level of uptake, distribution and durability of our neural exosomes
AB 126 distribution

Highlighted areas show concentration of exosomes in brain

90 Minutes:
Coronal mouse brain sections with labeled AB126
Neural exosome concentration 90mins
6 and 24 Hours:
Greater intensity throughout the brain and concentration in the cerebellum and basal ganglia
Neural exosome concentration 6&12 hours
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What makes AB126 unique?

Preclinical research with AB126 has demonstrated the ability to cross the blood brain barrier and concentrate in areas of the brain such as the cerebellum and basal ganglia, which are regions of the brain responsible for motor movements, procedural leaning and cognition. As such, it can act as a transformational platform for treating neurological conditions such as stroke and neurodegenerative disease.

Either as a therapeutic agent or as a payload delivery system for siRNA (small interfering RNA), ASOs (allele-specific oligonucleotides) and proteins such as mAbs (monoclonal antibodies), AB126 is capable of breaching the barrier that has hampered many major advances in the neurological arena for years.
Brain Network
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